Website Description
 
What's in Name?   
miRBase
  • The miRBase database is a searchable database of published miRNA sequences and annotation. 
  • Each entry in the miRBase Sequence database represents a predicted hairpin portion of a miRNA transcript (termed mir in the database), with information on the location and sequence of the mature miRNA sequence (termed miR).
  • Both hairpin and mature sequences are available for searching and browsing, and entries can also be retrieved by name, keyword, references and annotation. All sequence and annotation data are also available for download.
  • The miRBase Registry provides miRNA gene hunters with unique names for novel miRNA genes prior to publication of results. Visit the help pages for more information about the naming service.
miRTarBase
  • As a database, miRTarBase has accumulated more than 360,000 miRNA-target interactions (MTIs), which are collected by manually surveying pertinent literature after NLP of the text systematically to filter research articles related to functional studies of miRNAs. 
  • Generally, the collected MTIs are validated experimentally by reporter assay, western blot, microarray and next-generation sequencing experiments. 
  • While containing the largest amount of validated MTIs, the miRTarBase provides the most updated collection by comparing with other similar, previously developed databases.
mirPath

  • DIANA-mirPath is a miRNA pathway analysis web-server, providing accurate statistics, while being able to accommodate advanced pipelines. 

  • mirPath can utilize predicted miRNA targets (in CDS or 3’-UTR regions) provided by the DIANA-microT-CDS algorithm or even experimentally validated miRNA interactions derived from DIANA-TarBase. 

  • These interactions (predicted and/or validated) can be subsequently combined with sophisticated merging and meta-analysis algorithms.
Cancer-miRNA Regulatory Network
  • The cancer miRNA regulatory network was constructed by inferring miRNA mediated regulation for 2,240 gene co-expression signatures from 46 cancer transcriptome profiling studies. 
  • The cancer miRNA regulatory network can be used to identify clinically relevant miRNAs that are candidates for improved diagnostics, prognostics and therapeutics.
miRDB
  • miRDB is an online database for miRNA target prediction and functional annotations. 
  • All the targets in miRDB were predicted by a bioinformatics tool, MirTarget, which was developed by analyzing thousands of miRNA-target interactions from high-throughput sequencing experiments. 
  • Common features associated with miRNA target binding have been identified and used to predict miRNA targets with machine learning methods. 
  • miRDB hosts predicted miRNA targets in five species: human, mouse, rat, dog and chicken. 
  • As a recent update, users may provide their own sequences for customized target prediction. 
  • In addition, through combined computational analyses and literature mining, functionally active miRNAs in humans and mice were identified. These miRNAs, as well as associated functional annotations, are presented in the FuncMir Collection in miRDB.
Atlas of Genetics and Cytogenetics in Oncology

  • The Atlas of Genetics and Cytogenetics in Oncology and Haematology is a peer reviewed on-line journal, encyclopaedia and database in free access on the Internet, devoted to genes, cytogenetics, and clinical entities in cancer, and cancer-prone diseases.

  • It presents structured reviews (cards) or traditional review papers (deep insights), a portal towards genetics and/or cancer databases and journals, teaching items in Genetics for students in Medicine and in Sciences, and a case report in hematology section.

  • It is made for and by: clinicians and researchers in cytogenetics, molecular biology, oncology, haematology, and pathology. Contributions are reviewed before acceptance by members of the Editorial Board.